Best Weeks for All Players
*=Offensive Player of the Week *=Defensive Player of the Week
| Rank | Pos. | Player | Pro | Score | Week | Opponent | Breakdown |
| 1. | RB | Clinton Portis | Den | 55 | Week 14, 2003 * | KC | 218 Rush, 36 Receiving, 5 TD |
| 2. | RB | Shaun Alexander | Sea | 53 | Week 04, 2002 * | Min | 139 Rush, 92 Receiving, 5 TD |
| 3. | QB | Tom Brady | NE | 51 | Week 06, 2009 * | @ | 380 Pass, 6 TD |
| 3. | RB | Corey Dillon | Cin | 51 | Week 15, 1997 | @Ten | 246 Rush, 30 Receiving, 4 TD |
| 5. | QB | Tom Brady | NE | 50 | Week 07, 2007 * | @ | 354 Pass, 6 TD |
| 6. | QB | Carson Palmer | Cin | 49 | Week 02, 2007 * | @ | 401 Pass, 10 Rush, 6 TD, 2 Int |
| 6. | QB | Jeff Garcia | SF | 49 | Week 14, 2003 | Ari | 252 Pass, 32 Rush, 6 TD |
| 6. | RB | Mike Anderson | Den | 49 | Week 14, 2000 * | @NO | 251 Rush, 5 Receiving, 4 TD |
| 9. | QB | Drew Brees | NO | 48 | Week 01, 2009 * | @ | 358 Pass, 6 TD, 1 Int |
| 9. | RB | Adrian Peterson | Min | 48 | Week 09, 2007 * | @ | 296 Rush, 19 Receiving, 3 TD, 1 Fumb |
| 9. | QB | Daunte Culpepper | Min | 48 | Week 05, 2004 * | @Hou | 396 Pass, 30 Rush, 5 TD |
| 9. | QB | Peyton Manning | Ind | 48 | Week 04, 2003 * | @NO | 314 Pass, 1 Rush, 6 TD |
| 9. | RB | Priest Holmes | KC | 48 | Week 12, 2002 * | @Sea | 197 Rush, 110 Receiving, 3 TD |
| 9. | RB | Fred Taylor | Jac | 48 | Week 12, 2000 * | @Pit | 234 Rush, 14 Receiving, 4 TD |
| 15. | RB | Jerome Harrison | Cle | 47 | Week 15, 2009 | @ | 286 Rush, 12 Receiving, 3 TD |
| 15. | QB | Donovan McNabb | Phi | 47 | Week 13, 2004 * | GB | 464 Pass, 5 TD, 1 Fumb |
| 15. | RB | Marshall Faulk | StL | 47 | Week 07, 2002 * | Sea | 183 Rush, 52 Receiving, 4 TD |
| 15. | QB | Trent Green | KC | 47 | Week 04, 2002 | Mia | 328 Pass, 48 Rush, 5 TD |
| 15. | WR | Jimmy Smith | Jac | 47 | Week 02, 2000 * | @Bal | 291 Receiving, 3 TD |
| 15. | QB | Trent Green | Was | 47 | Week 12, 1998 * | Ari | 382 Pass, 26 Rush, 5 TD, 1 Int, 1 2-Pt |
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